Cornelia Quadt Selected Research

5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamide

7/2013	First-in-human phase I dose-escalation study of the HSP90 inhibitor AUY922 in patients with advanced solid tumors.
6/2013	The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth.
4/2013	Inhibition of HSP90 with AUY922 induces synergy in HER2-amplified trastuzumab-resistant breast and gastric cancer.
5/2010	89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922.
4/2010	Synergistic action of the novel HSP90 inhibitor NVP-AUY922 with histone deacetylase inhibitors, melphalan, or doxorubicin in multiple myeloma.
1/2008	NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models.

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Cornelia Quadt Research Topics

Disease

15	Neoplasms (Cancer) 03/2019 - 10/2006
8	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2008
2	Diarrhea 01/2019 - 01/2019
2	Hyperglycemia 01/2019 - 03/2014
2	Exanthema (Rash) 01/2019 - 03/2014
2	Multiple Myeloma 04/2010 - 11/2009
1	Nausea 01/2019
1	Vomiting 01/2019
1	Fatigue 01/2019
1	Thrombocytopenia (Thrombopenia) 01/2019
1	Stomatitis 01/2019
1	Neoplasm Metastasis (Metastasis) 02/2015
1	Communicable Diseases (Infectious Diseases) 02/2015
1	Lung Neoplasms (Lung Cancer) 07/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/2013
1	Stomach Neoplasms (Stomach Cancer) 04/2013
1	Ovarian Neoplasms (Ovarian Cancer) 05/2010
1	Carcinogenesis 01/2008
1	Prostatic Neoplasms (Prostate Cancer) 10/2006
1	Lymphopenia (Lymphocytopenia) 05/2006

Drug/Important Bio-Agent (IBA)

7	AlpelisibIBA 03/2019 - 07/2013
6	5- (2,4- dihydroxy- 5- isopropylphenyl)- 4- (4- morpholin- 4- ylmethylphenyl)isoxazole- 3- carboxylic acid ethylamideIBA 07/2013 - 01/2008
5	Pharmaceutical PreparationsIBA 02/2015 - 01/2008
4	Proteins (Proteins, Gene)FDA Link 07/2013 - 01/2008
4	Heat-Shock Proteins (Heat-Shock Protein)IBA 06/2013 - 01/2008
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2019 - 07/2013
2	Estrogen ReceptorsIBA 01/2019 - 01/2018
2	dactolisibIBA 01/2019 - 01/2018
2	Trastuzumab (Herceptin)FDA Link 01/2018 - 04/2013
2	ErbB Receptors (EGF Receptor)IBA 01/2018 - 06/2013
2	Biomarkers (Surrogate Marker)IBA 01/2016 - 02/2010
2	NVP-BKM120IBA 01/2016 - 03/2014
2	Phosphatidylinositols (Phosphatidylinositol)IBA 02/2015 - 09/2014
1	Fulvestrant (Faslodex)FDA Link 01/2019
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2019
1	MTOR InhibitorsIBA 01/2016
1	Phosphotransferases (Kinase)IBA 02/2015
1	Transaminases (Aminotransferases)IBA 03/2014
1	Insulin (Novolin)FDA Link 03/2014
1	Mechanistic Target of Rapamycin Complex 1IBA 07/2013
1	Everolimus FDA Link 07/2013
1	Biological ProductsIBA 06/2013
1	Tyrosine Kinase InhibitorsIBA 06/2013
1	ImmunosorbentsIBA 05/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2010
1	Cisplatin (Platino)FDA LinkGeneric 05/2010
1	EnzymesIBA 05/2010
1	89Zr-bevacizumabIBA 05/2010
1	Histone Deacetylase InhibitorsIBA 04/2010
1	Vorinostat FDA Link 04/2010
1	PanobinostatIBA 04/2010
1	Melphalan (Alkeran)FDA LinkGeneric 04/2010
1	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2010
1	NVP-BEP800IBA 11/2009
1	Molecular Chaperones (Chaperone, Molecular)IBA 11/2009
1	Hormones (Hormone)IBA 10/2006
1	Epithelial Cell Adhesion MoleculeIBA 10/2006
1	adecatumumabIBA 10/2006
1	CytokinesIBA 05/2006

Therapy/Procedure

5	Therapeutics 03/2019 - 04/2010
1	Drug Tapering 01/2019
1	Aftercare (After-Treatment) 07/2013